| 2025 | Book of Lives: A Memoir of Sorts | National Book Critics Circle Awards source ↗ (opens in a new tab) | Longlist · Autobiography | |
| 2025 | Book of Lives | TIME Best Books of the Year source ↗ (opens in a new tab) | Selection · 100 Must-Read | |
| 2025 | Book of Lives: A Memoir of Sorts | Financial Times Best Books of the Year source ↗ (opens in a new tab) | Selection · Audio | |
| 2025 | Book of Lives: A Memoir of Sorts | The Guardian Best Books of the Year source ↗ (opens in a new tab) | Selection · Biography and memoir | |
| 2025 | Book of Lives: A Memoir of Sorts | Chicago Public Library Best of the Best source ↗ (opens in a new tab) | Selection · Must-Read Books: Biography & Memoir | |
| 2025 | Book of Lives | The Globe and Mail Globe 100 source ↗ (opens in a new tab) | Selection · Non-Fiction | |
| 2025 | Book of Lives | Kirkus Best Books of the Year source ↗ (opens in a new tab) | Selection · Nonfiction | |
| 2025 | Book of Lives | New York Times 100 Notable Books source ↗ (opens in a new tab) | Selection · Nonfiction | |
| 2025 | Book of Lives: A Memoir of Sorts | The Boston Globe Best Books of the Year source ↗ (opens in a new tab) | Selection · Nonfiction | |
| 2025 | Book of Lives: A Memoir of Sorts | The Observer Best Books of the Year source ↗ (opens in a new tab) | Selection · Nonfiction | |
| 2025 | Book of Lives: A Memoir of Sorts | Washington Post Best Books of the Year source ↗ (opens in a new tab) | Selection · Notable Nonfiction | |
| 2024 | Fourteen Days | The New Yorker Best Books of the Year source ↗ (opens in a new tab) | Selection · Also Recommended | |
| 2024 | Paper Boat: New and Selected Poems 1961-2023 | Financial Times Best Books of the Year source ↗ (opens in a new tab) | Selection · Poetry | |
| 2023 | Old Babes in the Wood | The Globe and Mail Globe 100 source ↗ (opens in a new tab) | Selection · Fiction | |
| 2020 | Dearly | Goodreads Choice Awards source ↗ (opens in a new tab) | Winner · Poetry | |
| 2020 | The Testaments | Locus Awards source ↗ (opens in a new tab) | Finalist · SF Novel | |
| 2020 | The Testaments | British Book Awards source ↗ (opens in a new tab) | Shortlist · Fiction Book of the Year | |
| 2020 | Dearly | The Globe and Mail Globe 100 source ↗ (opens in a new tab) | Selection · Poetry | |
| 2020 | Dearly | Financial Times Best Books of the Year source ↗ (opens in a new tab) | Selection · Poetry | |
| 2020 | Dearly: New Poems | Library Journal Best Books source ↗ (opens in a new tab) | Selection · Poetry | |
| 2019 | The Testaments | Booker Prize source ↗ (opens in a new tab) | Winner · Fiction | |
| 2019 | The Testaments | Goodreads Choice Awards source ↗ (opens in a new tab) | Winner · Fiction | |
| 2019 | The Testaments | Barnes & Noble Book of the Year source ↗ (opens in a new tab) | Finalist · Book of the Year | |
| 2019 | The Testaments | Waterstones Book of the Year source ↗ (opens in a new tab) | Shortlist · Book of the Year | |
| 2019 | The Testaments | Scotiabank Giller Prize source ↗ (opens in a new tab) | Longlist · Fiction | |
| 2019 | The Testaments | Chicago Public Library Best of the Best source ↗ (opens in a new tab) | Selection · Best Books | |
| 2019 | The Testaments | New York Public Library Best Books source ↗ (opens in a new tab) | Selection · Best Books for Adults | |
| 2019 | The Testaments: The Sequel To The Handmaid's Tale | NPR Books We Love source ↗ (opens in a new tab) | Selection · Books We Love | |
| 2019 | The Testaments | The Irish Times Best Books of the Year source ↗ (opens in a new tab) | Selection · Books of the Year | |
| 2019 | The Testaments | The Globe and Mail Globe 100 source ↗ (opens in a new tab) | Selection · Fiction | |
| 2019 | The Testaments | Financial Times Best Books of the Year source ↗ (opens in a new tab) | Selection · Fiction | |
| 2019 | The Testaments | The Guardian Best Books of the Year source ↗ (opens in a new tab) | Selection · Fiction | |
| 2019 | The Testaments | TIME Best Books of the Year source ↗ (opens in a new tab) | Selection · Fiction | |
| 2019 | The Testaments | BookPage Best Books of the Year source ↗ (opens in a new tab) | Selection · Fiction | |
| 2019 | The Testaments | New York Times 100 Notable Books source ↗ (opens in a new tab) | Selection · Fiction & Poetry | |
| 2019 | The Testaments | Washington Post Best Books of the Year source ↗ (opens in a new tab) | Selection · Notable Fiction | |
| 2019 | The Testaments | Amazon Editors' Best Books of the Year source ↗ (opens in a new tab) | Selection · Top 10 | |
| 2017 | Hag-Seed | Women's Prize for Fiction source ↗ (opens in a new tab) | Longlist · Fiction | |
| 2017 | The Heart Goes Last | Dublin Literary Award source ↗ (opens in a new tab) | Longlist · Fiction | |
| 2016 | Hag-Seed | NPR Books We Love source ↗ (opens in a new tab) | Selection · Books We Love | |
| 2016 | Hag-Seed | The Guardian Best Books of the Year source ↗ (opens in a new tab) | Selection · Fiction | |
| 2016 | Hag-Seed | Paste Best Books of the Year source ↗ (opens in a new tab) | Selection · Fiction | |
| 2015 | The Heart Goes Last | The Kitschies source ↗ (opens in a new tab) | Winner · Red Tentacle (Novel) | |
| 2015 | MaddAddam | Dublin Literary Award source ↗ (opens in a new tab) | Longlist · Fiction | |
| 2015 | The Heart Goes Last | Goodreads Choice Awards source ↗ (opens in a new tab) | Nominee · Science Fiction | |
| 2015 | The Heart Goes Last | BookPage Best Books of the Year source ↗ (opens in a new tab) | Selection · Best Books | |
| 2015 | The Heart Goes Last | The Telegraph Best Books of the Year source ↗ (opens in a new tab) | Selection · Best Books | |
| 2015 | The Heart Goes Last | The Boston Globe Best Books of the Year source ↗ (opens in a new tab) | Selection · Fiction | |
| 2015 | The Heart Goes Last | The Globe and Mail Globe 100 source ↗ (opens in a new tab) | Selection · Fiction | |
| 2015 | The Heart Goes Last | The Guardian Best Books of the Year source ↗ (opens in a new tab) | Selection · Fiction | |
| 2014 | MaddAddam | Locus Awards source ↗ (opens in a new tab) | Finalist · SF Novel | |
| 2014 | MaddAddam | Women's Prize for Fiction source ↗ (opens in a new tab) | Longlist · Fiction | |
| 2014 | Stone Mattress | Goodreads Choice Awards source ↗ (opens in a new tab) | Nominee · Fiction | |
| 2014 | Stone Mattress: Nine Tales | NPR Books We Love source ↗ (opens in a new tab) | Selection · Books We Love | |
| 2014 | Stone Mattress | The Globe and Mail Globe 100 source ↗ (opens in a new tab) | Selection · Fiction | |
| 2014 | Stone Mattress | Publishers Weekly Best Books source ↗ (opens in a new tab) | Selection · Fiction | |
| 2013 | MaddAddam | Goodreads Choice Awards source ↗ (opens in a new tab) | Winner · Science Fiction | |
| 2013 | MaddAddam: A Novel | NPR Books We Love source ↗ (opens in a new tab) | Selection · Books We Love | |
| 2013 | MaddAddam | The Irish Times Best Books of the Year source ↗ (opens in a new tab) | Selection · Books of the Year | |
| 2013 | MaddAddam | Publishers Weekly Best Books source ↗ (opens in a new tab) | Selection · Fiction | |
| 2013 | Maddaddam | The Globe and Mail Globe 100 source ↗ (opens in a new tab) | Selection · Fiction | |
| 2013 | Maddaddam | New York Times 100 Notable Books source ↗ (opens in a new tab) | Selection · Fiction & Poetry | |
| 2013 | MaddAddam | Washington Post Best Books of the Year source ↗ (opens in a new tab) | Selection · Notable Fiction | |
| 2013 | MaddAddam | The Guardian Best Books of the Year source ↗ (opens in a new tab) | Selection · Science fiction and fantasy | |
| 2011 | The Year of the Flood | Dublin Literary Award source ↗ (opens in a new tab) | Longlist · Fiction | |
| 2010 | The Year of the Flood | John W. Campbell Memorial Award for Best Science Fiction Novel source ↗ (opens in a new tab) | Finalist · Best Science Fiction Novel | |
| 2009 | The Year of the Flood | Scotiabank Giller Prize source ↗ (opens in a new tab) | Longlist · Fiction | |
| 2009 | The Year of the Flood | Kirkus Best Books of the Year source ↗ (opens in a new tab) | Selection · Adult | |
| 2009 | The Year of the Flood | Booklist Editors' Choice source ↗ (opens in a new tab) | Selection · Adult Books: Fiction | |
| 2009 | The Year of the Flood | The Globe and Mail Globe 100 source ↗ (opens in a new tab) | Selection · Fiction | |
| 2009 | The Year of the Flood | The Guardian Best Books of the Year source ↗ (opens in a new tab) | Selection · Fiction | |
| 2009 | The Year of the Flood | New York Times 100 Notable Books source ↗ (opens in a new tab) | Selection · Fiction & Poetry | |
| 2009 | The Year of the Flood | Amazon Editors' Best Books of the Year source ↗ (opens in a new tab) | Selection · Top 100 | |
| 2008 | Moral Disorder | Dublin Literary Award source ↗ (opens in a new tab) | Longlist · Fiction | |
| 2008 | Payback | The Globe and Mail Globe 100 source ↗ (opens in a new tab) | Selection · Non-Fiction | |
| 2008 | Payback | Washington Post Best Books of the Year source ↗ (opens in a new tab) | Selection · Notable Nonfiction | |
| 2007 | The Door: Poems | Governor General's Literary Awards source ↗ (opens in a new tab) | Finalist · Poetry | |
| 2007 | The Penelopiad | Dublin Literary Award source ↗ (opens in a new tab) | Longlist · Fiction | |
| 2006 | The Penelopiad | Mythopoeic Fantasy Awards source ↗ (opens in a new tab) | Finalist · Adult Literature | |
| 2006 | Moral Disorder: Stories | Washington Post Best Books of the Year source ↗ (opens in a new tab) | Selection · Notable Fiction | |